HX 531 |
| رقم الكتالوجGC16814 |
HX 531 هو مضاد قوي لـ RXR مع IC50 18 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188844-34-0
Sample solution is provided at 25 µL, 10mM.
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HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid -induced transactivation of RXR.[1] It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.[2]
Reference:
[1]. Konta, T., Xu, Q., Furusu, A., et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J. Biol. Chem. 276(16), 12697-12701 (2001).
[2]. Yamauchi, T., Waki, H., Kamon, J., et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108(7), 1001-1013 (2001).
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