iMDK quarterhydrate |
| رقم الكتالوجGC62376 |
iMDK ربع هيدرات هو مثبط قوي لـ PI3K ويثبط عامل النمو MDK (المعروف أيضًا باسم midkine أو MK)يثبط ربع هيدرات iMDK سرطان الرئة ذو الخلايا غير الصغيرة (NSCLC) بالتعاون مع مثبط MEK دون الإضرار بالخلايا والفئران السليمة
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1].
PD0325901 enhances growth inhibition in H441, H2009 and H520 and A549 NSCLC cells after iMDK quarterhydrate treatment[1].iMDK (50-500 nM) quarterhydrate suppressed AKT phosphorylation in a dose-dependent manner in H441 lung adenocarcinoma cells after treatment for 72 h. In contrast, iMDK quarterhydrate robustly increases p-ERK[1].
The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1].
[1]. Naomasa Ishida, et al. A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor. Exp Cell Res. 2015 Jul 15;335(2):197-206.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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