Indacrinone (MK196) |
| رقم الكتالوجGC31582 |
Indacrinone (MK196) (MK196) هو مدر للبول استقصائي أظهر نشاط ملحي في الجرذان والكلب بالإضافة إلى نشاط حمض اليوريك ونشاطه في الشمبانزي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56049-88-8
Sample solution is provided at 25 µL, 10mM.
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Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1].
[1]. A.G. ZACCHEI, et al. THE PHYSIOLOGICAL DISPOSITION
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