JB170 |
| رقم الكتالوجGC63707 |
JB170 عبارة عن مزيل مواد AURORA-A بوساطة PROTAC قوي وعالي التحديد (أورورا كيناز) (DC50 = 28 نانومتر) عن طريق ربط Alisertib بجزيء Cereblon المرتبط بالثاليدوميديربط JB170 بشكل تفضيلي AURORA-A (EC50 = 193 نانومتر) على AURORA-B (EC50 = 1.4 ميكرومتر)يحدث توقف المرحلة S بوساطة JB170 بسبب استنفاد AURORA-A على وجه التحديديتمتع JB170 بقدرة ممتازة على تثبيط الوظيفة غير التحفيزية لـ AURORA-A kinase
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Cas No.: 2705844-82-0
Sample solution is provided at 25 µL, 10mM.
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JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase[1].
JB170 (1 μM; 24-72 hours; MV4-11 cells) mediates Aurora-A depletion inhibiting cancer cell survival[1]. JB170 (0.01-10 μM; 6 hours; MV4-11 cells) reduces AURORA-A levels [1].JB170 (0.5 μM; 12 hours; MV4-11 cells) delays/arrests S-phase progression[1].JB170 (0.5 μM; 0-72 hours; MV4-11 cells) induces apoptosis is exclusively caused by targeting AURORA-A[1].JB170 (0.1 µM; 0-9 hours; IMR5 cells) shows rapid AURORA-A depletion. JB170 (0~1 μM; 6 hours; MV4-11 cells) strongly attenuates in mutants with respect to AURORA-A. JB170 (0.1 μM; 18 hours; MV4-11 cells) does not activate AURORA-A. JB170 (0~1 µM; 24 hours; IMR5 cells) largely abrogates AURORA-AT217D depletion. JB170 (1 μM; 4 days; IMR5 cells) mediates Aurora-A depletion inhibiting cancer cell survival. JB170 (IMR5 cells) reduces AURORA-A levels by lowering AURORA-A mRNA levels[1].
[1]. Adhikari B, et al. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nat Chem Biol. 2020;16(11):1179-1188.
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