JP-1302 (hydrochloride) |
| رقم الكتالوجGC43932 |
JP-1302 (هيدروكلوريد) هو مضاد انتقائي عالي التقارب لمستقبل alpha2C-adrenoceptor (α ؛ 2C-adrenoceptor) ، مع قيمة Kb (نشاط مضاد) تبلغ 16 نانومتر وقيمة Ki (تقارب الارتباط) تبلغ 28 نانومتر.
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Cas No.: 1259314-65-2
Sample solution is provided at 25 µL, 10mM.
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JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively). It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice. JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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