Levonordefrin (Synonyms: Corbadrine, (–)-α-methyl Noradrenaline, (–)-3,4-dihydroxy Norephedrine) |
| رقم الكتالوجGC40807 |
يستخدم Levonordefrin ، وهو بديل شائع لـ levoepinephrine كمضيق للأوعية في مستحضرات التخدير الموضعي للأسنان ، بتركيزات أعلى بخمسة أضعاف
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Cas No.: 829-74-3
Sample solution is provided at 25 µL, 10mM.
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Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine , that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%. Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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