Levonordefrin (Synonyms: Corbadrine, (–)-α-methyl Noradrenaline, (–)-3,4-dihydroxy Norephedrine) |
| カタログ番号GC40807 |
レボノルデフリンは、歯科用局所麻酔薬の血管収縮剤としてレボエピネフリンの一般的な代替品であり、通常は 5 倍高い濃度で使用されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 829-74-3
Sample solution is provided at 25 µL, 10mM.
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Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine , that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%. Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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