LM 10 |
| رقم الكتالوجGC50265 |
LM 10 هو مثبط قوي للتربتوفان 2،3-ديوكسيجيناز (TDO). التربتوفان 2،3-ديوكسجيناز (TDO) هو إنزيم كبدي غير مرتبط يعمل أيضًا على تحطيم التربتوفان على طول مسار كينورينين. LM 10 لديه القدرة على البحث عن أمراض السرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1316695-35-8
Sample solution is provided at 25 µL, 10mM.
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Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID:22308364 |Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID:21726069
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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