LM 10 |
| Katalog-Nr.GC50265 |
LM 10 ist ein potenter Inhibitor der Tryptophan-2,3-Dioxygenase (TDO). Tryptophan-2,3-Dioxygenase (TDO) ist ein nicht verwandtes hepatisches Enzym, das Tryptophan ebenfalls entlang des Kynurenin-Wegs abbaut. LM 10 hat das Potenzial für die Erforschung von Krebserkrankungen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1316695-35-8
Sample solution is provided at 25 µL, 10mM.
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Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.
Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID:22308364 |Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID:21726069
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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