LM11A-31 (hydrochloride) |
| رقم الكتالوجGC18175 |
LM11A-31 (هيدروكلوريد) ، مُعدِّل p75NTR (مستقبلات نيوروتروفين p75) غير الببتيد ، هو مضاد فعال عن طريق الفم وقوي proNGF (عامل نمو الأعصاب).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1243259-19-9
Sample solution is provided at 25 µL, 10mM.
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LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand that inhibits nerve growth factor (NGF) binding to p75NTR-Fc (A2 = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPPLond/Swe and Tg2576 mice with mid- to late stage Alzheimer's disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington's disease.
Review for LM11A-31 (hydrochloride)
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
Review for LM11A-31 (hydrochloride)
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