Arachidonoyl Cyclopropylamide (Synonyms: ACPA) |
| رقم الكتالوجGC18615 |
أراكيدونويل سيكلوبروبيلاميد (ACPA) هو محفز قوي وانتقائي لمستقبلات الكانابينود (CB) المستقبل 1 بقيم Ki تصل إلى 2.2 و715 نانومترًا لمستقبلات CB1 و CB2 على الترتيب.
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Cas No.: 229021-64-1
Sample solution is provided at 25 µL, 10mM.
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Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
References:
[1].Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).
[2]. Hillard, C.J., Manna, S., Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1) J. Pharmacol. Exp. Ther. 289(3), 1427-1433 (1999).
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