m-PEG8-Amine |
| رقم الكتالوجGC62543 |
m-PEG8-Amine عبارة عن رابط ADC قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)
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Cas No.: 869718-81-0
Sample solution is provided at 25 µL, 10mM.
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m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Joshua D. Thoma, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.
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