الصفحة الرئيسية>>Signaling Pathways>> Antibody-drug Conjugate/ADC Related>> ADC Linker>>MC-Gly-Gly-Phe

MC-Gly-Gly-Phe

رقم الكتالوجGC38926

MC-Gly-Gly-Phe عبارة عن رابط قابل للانقسام يستخدم في اتحادات الأدوية والأجسام المضادة (ADC)

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MC-Gly-Gly-Phe التركيب الكيميائي

Cas No.: 1599440-15-9

الحجم السعر المخزون الكميّة
100mg
24٫00
متوفر
500mg
36٫00
متوفر
1g
54٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description of MC-Gly-Gly-Phe

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).

[1]. Antibody-drug conjugate. WO2014057687A1.

Chemical Properties of MC-Gly-Gly-Phe

Cas No. 1599440-15-9 SDF
Canonical SMILES O=C(O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Formula C23H28N4O7 M.Wt 472.49
الذوبان DMSO: 50 mg/mL (105.82 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of MC-Gly-Gly-Phe

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1164 mL 10.5822 mL 21.1645 mL
5 mM 0.4233 mL 2.1164 mL 4.2329 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL
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In vivo Formulation Calculator (Clear solution) of MC-Gly-Gly-Phe

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for MC-Gly-Gly-Phe

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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