Mcl1-IN-8 |
| رقم الكتالوجGC38811 |
Mcl1-IN-8 (المركب 8) هو مثبط واجهة Mcl-1-PUMA النشط عن طريق الفم ، مع Ki 0.3 μ ؛ M. يُظهر Mcl1-IN-8 نشاطًا مزدوجًا في تقليل موت الخلايا المبرمج المعتمد على PUMA أثناء إلغاء تنشيط Mcl-1 بوساطة مكافحة موت الخلايا المبرمج في الخلايا السرطانية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 678158-55-9
Sample solution is provided at 25 µL, 10mM.
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Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.
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