Methyl azetidine-3-carboxylate hydrochloride |
| رقم الكتالوجGC64174 |
ميثيل أزيتيدين -3 كربوكسيلات هيدروكلوريد هو رابط ADC غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)ميثيل أزيتيدين -3 كربوكسيلات هيدروكلوريد هو أيضًا رابط PROTAC قائم على سلسلة الألكيل يمكن استخدامه في تخليق PROTACs <
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Cas No.: 100202-39-9
Sample solution is provided at 25 µL, 10mM.
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Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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