Mitomycin A (Synonyms: NSC 75986) |
| رقم الكتالوجGC44200 |
Mitomycin A is a bacterial metabolite originally isolated from S.
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Cas No.: 4055-39-4
Sample solution is provided at 25 µL, 10mM.
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Mitomycin A is a bacterial metabolite originally isolated from S. caespitosus. It reduces migration inhibition factor (MIF) production by isolated human lymphocytes when used at a concentration of 0.25 µg/ml and decreases spontaneous migration of WEHI-3 murine monocytes when used at concentrations of 0.5 and 5 µg/ml. Mitomycin A forms intra- and interstrand adducts with DNA in the presence of thiols, such as dithiothreitol (DTT). It reduces tumor growth in P388 leukemia and B16 melanoma mouse models with a minimum effective dose (MED) of 0.05 mg/kg for both but is toxic to mice with an LD50 value of 2 mg/kg.
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