MK 886 (Synonyms: L-663,536) |
| رقم الكتالوجGC12277 |
MK 886 (L 663536) هو مثبط قوي ، نافذ للخلايا ونشط عن طريق الفم (IC50 من 30 نانومتر) والتخليق الحيوي الليكوترين (IC50s من 3 نانومتر و 1.1 ميكرومتر في الكريات البيض السليمة والدم البشري الكامل ، على التوالي). MK 886 هو أيضًا مضاد PPARα غير تنافسي ويمكن أن يحفز موت الخلايا المبرمج.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 118414-82-7
Sample solution is provided at 25 µL, 10mM.
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MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).
References:
[1]. [1] Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15.
[2]. [2] Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
[3]. [3] Dixon RA et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990 Jan 18, 343(6255):282-4.http://www.ncbi.nlm.nih.gov/pubmed/2300173
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