MK 886 (Synonyms: L-663,536) |
| Katalog-Nr.GC12277 |
MK 886 (L 663536) ist ein potenter, zellgängiger und oral aktiver Inhibitor der FLAP (IC50 von 30 nM) und der Leukotrien-Biosynthese (IC50 von 3 nM bzw. 1,1 μM in intakten Leukozyten bzw. menschlichem Vollblut). MK 886 ist auch ein nicht-kompetitiver PPARα-Antagonist und kann Apoptose induzieren.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 118414-82-7
Sample solution is provided at 25 µL, 10mM.
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MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).
References:
[1]. [1] Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15.
[2]. [2] Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
[3]. [3] Dixon RA et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990 Jan 18, 343(6255):282-4.http://www.ncbi.nlm.nih.gov/pubmed/2300173
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