ML-180 (Synonyms: CID3238389, SR1848) |
| رقم الكتالوجGC44216 |
ML-180 (SR1848) هو ناهض عكسي لمستقبلات الكبد اليتيم 1 (LRH-1 ؛ NR5A2) مع IC50 من 3.7 ميكرومترML-180 غير نشط للعامل الستيرويدي المنشأ -1 (SF-1 ؛ NR5A1 ؛ IC50> 10 ميكرومتر)ML-180 لديه القدرة على الإصابة بسرطانات تعتمد على LRH-1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 863588-32-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 µM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 µM).
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *