ML-299 (Synonyms: CID 56593087) |
| رقم الكتالوجGC44223 |
ML-299 هو معدل خيفي انتقائي ومثبط مزدوج للفوسفوليباز D1 و D2 (قيم IC هي 6 و 12 نانومتر ، على التوالي). يقلل ML-299 الهجرة الغازية في خلايا الورم الأرومي الدبقي U87-MG.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1426916-00-8
Sample solution is provided at 25 µL, 10mM.
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ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively). It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel. ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally. As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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