ML-299 (Synonyms: CID 56593087) |
Catalog No.GC44223
One-Click Copy Product Info
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ML-299는 선택적 알로스테릭 조절제이자 포스포리파제 D1 및 D2의 이중 억제제입니다(IC50 값은 각각 6 및 12 nM임). ML-299는 U87-MG 교모세포종 세포에서 침습적 이동을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1426916-00-8
Sample solution is provided at 25 µL, 10mM.
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ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively). It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel. ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally. As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.
| Cas No. | 1426916-00-8 | SDF | |
| Synonyms | CID 56593087 | ||
| Canonical SMILES | BrC1=CC=C(C(N[C@@H](C)CN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1 | ||
| Formula | C23H26BrFN4O2 | M.Wt | 489.4 |
| Solubility | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:20): 0.5 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0433 mL | 10.2166 mL | 20.4332 mL |
| 5 mM | 408.7 μL | 2.0433 mL | 4.0866 mL |
| 10 mM | 204.3 μL | 1.0217 mL | 2.0433 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)