ML-299 (Synonyms: CID 56593087) |
| Catalog No.GC44223 |
ML-299는 선택적 알로스테릭 조절제이자 포스포리파제 D1 및 D2의 이중 억제제입니다(IC50 값은 각각 6 및 12 nM임). ML-299는 U87-MG 교모세포종 세포에서 침습적 이동을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1426916-00-8
Sample solution is provided at 25 µL, 10mM.
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ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively). It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel. ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally. As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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