ML 349 |
| رقم الكتالوجGC17889 |
ML 349 هو مثبط قوي ومحدد لبروتين الأسيل ثيويستيراز 2 (APT2) / ليسوفوسفوليباز 2 (LYPLA2) مع Ki يبلغ 120 نانومتر. ML 349 هو أيضًا مثبط لـ LYPLA2 مع IC50 من 144 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 890819-86-0
Sample solution is provided at 25 µL, 10mM.
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ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively[1]. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells[3].
References:
[1]. Won SJ, et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.
[2]. Adibekian A, et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).
[3]. Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.
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