MLS000544460 |
| رقم الكتالوجGC61408 |
MLS000544460 هو مثبط Eya2 الفوسفاتيز انتقائي للغاية وقابل للانعكاس مع Kd 2.0 ميكرومتر و IC50 من 4 ميكرومترMLS000544460 يمنع هجرة الخلايا Eya2 فسفاتيز بوساطة وله نشاط مضاد للسرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 352336-36-8
Sample solution is provided at 25 µL, 10mM.
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MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1].
MLS000544460 does not bind Eya3 phosphatase (ED)[1]. MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells[1]. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED[1].
[1]. Krueger AB, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cellmigration. J Biol Chem. 2014 Jun 6;289(23):16349-61.
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