MLS000544460 |
| Catalog No.GC61408 |
MLS000544460은 Kd가 2.0μM이고 IC50이 4μM인 고도로 선택적이고 가역적인 Eya2 포스파타제 억제제입니다. MLS000544460은 Eya2 포스파타제 매개 세포 이동을 억제하고 항암 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 352336-36-8
Sample solution is provided at 25 µL, 10mM.
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MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1].
MLS000544460 does not bind Eya3 phosphatase (ED)[1]. MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells[1]. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED[1].
[1]. Krueger AB, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cellmigration. J Biol Chem. 2014 Jun 6;289(23):16349-61.
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