N-Arachidonoyl Taurine-d4 |
رقم الكتالوجGC47749
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N-Arachidonoyl taurine-d4 is intended for use as an internal standard for the quantification of N-arachidonoyl taurine by GC- or LC-MS. N-Arachidonoyl taurine is an arachidonoyl amino acid.1 It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages.2 N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively).1 It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells.3 The levels of N-arachidonoyl taurine are changed in mouse brain following administration of δ9-tetrahydrocannabinol (δ9-THC).4
1.Saghatelian, A., McKinney, M.K., Bandell, M., et al.A FAAH-regulated class of N-acyl taurines that activates TRP ion channelsBiochemistry45(30)9007-9015(2006) 2.Turman, M.V., Kingsley, P.J., Rouzer, C.A., et al.Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurineBiochemistry47(12)3917-3925(2008) 3.Waluk, D.P., Vielfort, K., Derakhshan, S., et al.N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cellsBiochem. Biophys. Res. Commun.430(1)54-59(2013) 4.Leishman, E., Murphy, M., Mackie, K., et al.δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adultBiochim. Biophys. Acta. Mol. Cell Biol. Lipids1863(5)479-492(2018)
| Cas No. | SDF | ||
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC([2H])([2H])C([2H])([2H])S(=O)(O)=O)=O | ||
| Formula | C22H33D4NO4S | M.Wt | 415.6 |
| الذوبان | DMF: 10 mg/mL,DMSO: 20 mg/mL,PBS (pH 7.2): 1.5 mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4062 mL | 12.0308 mL | 24.0616 mL |
| 5 mM | 481.2 μL | 2.4062 mL | 4.8123 mL |
| 10 mM | 240.6 μL | 1.2031 mL | 2.4062 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solution in ethanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)