N-Boc-PEG6-alcohol |
| رقم الكتالوجGC64355 |
N-Boc-PEG6-alcohol عبارة عن رابط PROTAC قائم على PEG / Alkyl / ether يمكن استخدامه في تخليق PROTACsN-Boc-PEG6-alcohol عبارة عن رابط ADC قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والعقاقير (ADCs)
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Cas No.: 331242-61-6
Sample solution is provided at 25 µL, 10mM.
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N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.
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