N3-PEG3-CH2CH2-Boc |
رقم الكتالوجGC65822 |
N3-PEG3-CH2CH2-Boc عبارة عن رابط PEG ADC قابل للانقسام مكون من 3 وحدات يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs). N3-PEG3-CH2CH2-Boc هو أيضًا رابط PROTAC قائم على PEG و Alkyl / ether والذي يمكن استخدامه في تخليق PROTACs.
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Cas No.: 252881-73-5
Sample solution is provided at 25 µL, 10mM.
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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