Nastorazepide (Synonyms: Z-360) |
| رقم الكتالوجGC19258 |
Nastorazepide (Z-360) هو أحد مضادات مستقبلات الغاسترين / كوليسيستوكينين 2 (CCK-2) الانتقائي المتاح عن طريق الفم ، مع نشاط محتمل لمضادات الأورام
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Cas No.: 209219-38-5
Sample solution is provided at 25 µL, 10mM.
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Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target:CCK-2in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.
References:
[1]. Kato H, et al. CCK-2/gastrin receptor signaling pathway is significant for gemcitabine-induced gene expression of VEGF in pancreatic carcinoma cells. Life Sci. 2011 Oct 24;89(17-18):603-8.
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