Nevanimibe hydrochloride (Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride) |
| رقم الكتالوجGC65200 |
نيفانيميب هيدروكلوريد (PD-132301 هيدروكلوريد) هو أنزيم أسيل المساعد A النشط عن طريق الفم وانتقائي: مثبط الكوليسترول O-acyltransferase 1 (ACAT1) مع EC50 من 9 نانومترهيدروكلوريد نيفانيميب يثبط ACAT2 مع EC50 من 368 نانومتريحفز هيدروكلوريد نيفانيميب موت الخلايا المبرمج ولديه احتمال الإصابة بسرطان قشر الكظر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 133825-81-7
Sample solution is provided at 25 µL, 10mM.
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Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].
Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1].
[1]. LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157(5):1775-88.
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