NG 012 (Synonyms: BK223-A) |
| رقم الكتالوجGC44389 |
تم عزل NG 012 ، محفز عامل النمو العصبي (NGF) ، من مرق استنبات Penicillium verruculosum F-4542. NG 012 يقوي ثمرة النيرت الناجم عن NGF في خط خلايا ورم القواتم (PC12).
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Cas No.: 141731-76-2
Sample solution is provided at 25 µL, 10mM.
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NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties. It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro. NG 012 (50 μM) increases the efficacy of the antifungal miconazole against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.
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