NG 012 (Synonyms: BK223-A) |
| Katalog-Nr.GC44389 |
NG 012, Potentiator des Nervenwachstumsfaktors (NGF), wurde aus der Kulturbrühe von Penicillium verruculosum F-4542 isoliert. NG 012 potenziert das durch NGF induzierte Neuritenwachstum in der Ratten-Phäochromozytom-Zelllinie (PC12).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 141731-76-2
Sample solution is provided at 25 µL, 10mM.
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NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties. It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro. NG 012 (50 μM) increases the efficacy of the antifungal miconazole against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.
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