Noradrenaline bitartrate |
رقم الكتالوجGC50113
One-Click Copy Product Info
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نورابينفرين (ليفارترينول ، إل نورادرينالين) طرطرات هو ناهض قوي لمستقبلات الأدرينالين (AR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 51-40-1
Sample solution is provided at 25 µL, 10mM.
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Noradrenaline bitartrate is a β1-selective adrenergic receptor agonist with an EC50 value of 5.37μM [1]. Noradrenaline bitartrate enhances long-term memory consolidation in the amygdala and hippocampus through actions at α-1 and β adrenoceptors can enhance long-term memory consolidation in the amygdala and hippocampus through actions at α-1 and β adrenoceptors [2]. Noradrenaline bitartrate has been widely used to promote the contraction of mesenteric arteries[3].
In vitro, Noradrenaline bitartrate (1μM) treatment for 6 days protected rat dopaminergic neuronal cells from death and reduced intracellular reactive oxygen species (ROS) levels[4]. Treatment with Noradrenaline bitartrate (50μM) for 3 minutes significantly depolarized the membrane potential of pyramidal neurons in the medial prefrontal cortex[5]. 30μM of Noradrenaline bitartrate pretreatment for 24 hours significantly attenuated H2O2-induced cell death in SH-SY5Y cells[6]. Treatment with 1μM Noradrenaline bitartrate for 24 hours significantly reduced the release of IL-6 and TNF-alpha in microglial cells stimulated by lipopolysaccharide (LPS)[7].
References:
[1] MacGregor D A, Prielipp R C, Butterworth IV J F, et al. Relative efficacy and potency of β-adrenoceptor agonists for generating cAMP in human lymphocytes[J]. Chest, 1996, 109(1): 194-200.
[2] Ramos B P, Arnsten A F T. Adrenergic pharmacology and cognition: focus on the prefrontal cortex[J]. Pharmacology & therapeutics, 2007, 113(3): 523-536.
[3] Furness J B. The physiological relevance of constriction of mesenteric arteries by topically applied noradrenaline[J]. The Journal of physiology, 2017, 595(21): 6783.
[4] Troadec J D, Marien M, Darios F, et al. Noradrenaline provides long‐term protection to dopaminergic neurons by reducing oxidative stress[J]. Journal of neurochemistry, 2001, 79(1): 200-210.
[5] Grzelka K, Kurowski P, Gawlak M, et al. Noradrenaline modulates the membrane potential and holding current of medial prefrontal cortex pyramidal neurons via β1-adrenergic receptors and HCN channels[J]. Frontiers in cellular neuroscience, 2017, 11: 341.
[6] Yoshioka Y, Negoro R, Kadoi H, et al. Noradrenaline protects neurons against H2O2‐induced death by increasing the supply of glutathione from astrocytes via β3‐adrenoceptor stimulation[J]. Journal of Neuroscience Research, 2021, 99(2): 621-637.
[7] Färber K, Pannasch U, Kettenmann H. Dopamine and noradrenaline control distinct functions in rodent microglial cells[J]. Molecular and Cellular Neuroscience, 2005, 29(1): 128-138.
| Cell experiment [1]: | |
Cell lines | SH-SY5Y cells |
Preparation Method | SH-SY5Y cells were incubated with DMEM medium supplemented with 10% fetal calf serum (FCS) in a humidified atmosphere at 37°C with 5% CO2. SH-SY5Y cells were plated at a density of 0.9×104/well in 96-well tissue culture plate for 24h and were incubated for 24h in fresh culture medium containing with different concentrations of Noradrenaline bitartrate (1, 3, 10, and 30μM). Then the culture medium was aspirated and replaced with fresh medium containing 500µM H2O2. The cell viability of SH-SY5Y cells was determined. |
Reaction Conditions | 1, 3, 10, and 30μM; 24h |
Applications | Noradrenaline bitartrate treatment significantly reduced H2O2-induced death of SH-SY5Y cells in a dose-dependent manner. |
References: | |
| Cas No. | 51-40-1 | SDF | |
| Canonical SMILES | O[C@@H](CN)C1=CC(O)=C(O)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O | ||
| Formula | C8H11NO3.C4H6O6 | M.Wt | 319.26 |
| الذوبان | 31.93mg/mL in DMSO, 31.93mg/mL in Water | Storage | Store at 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1322 mL | 15.6612 mL | 31.3224 mL |
| 5 mM | 626.4 μL | 3.1322 mL | 6.2645 mL |
| 10 mM | 313.2 μL | 1.5661 mL | 3.1322 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)