Norfluoxetine (hydrochloride) (Synonyms: Desmethylfluoxetine) |
| رقم الكتالوجGC44451 |
نورفلوكستين (هيدروكلوريد) هو مستقلب نشط N-demethylated من فلوكستين.
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Cas No.: 57226-68-3
Sample solution is provided at 25 µL, 10mM.
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Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35 [1] . The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).[1][2]
Reference:
[1]. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).
[2]. Hiemke, C., and Härtter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & Therapeutics 85(1), 11-28 (2000).
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