Oleoyl Ethyl Amide (Synonyms: OEtA,N-Ethyloleamide) |
رقم الكتالوجGC15231 |
FAAH inhibitor with potential analgesic and anxiolytic activity
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 85075-82-7
Sample solution is provided at 25 µL, 10mM.
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity [1].
Fatty acid amide hydrolase (FAAH) is an integral membrane hydrolase and a member of the serine hydrolase family of enzymes. In vitro, FAAH has esterase and amidase activity. In vivo, FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs).
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor. In rat brain homogenates, Oleoyl Ethyl Amide inhibited FAAH activity with IC50 value of 5.25 nM, but did not bind to CB1 or CB2 receptors, or inhibit acidic PEAase. Oleoyl Ethyl Amide is a potent and selective FAAH inhibitor with potential analgesic and anxiolytic activity [1].
In Sprague-Dawley rats, subcutaneous injections of OEtA (0.3 mg/kg) for 2 weeks increased values of micturition intervals (MI) and volumes (MV), bladder capacity (BC), threshold pressure, and flow pressure. OEtA altered sensory urodynamic parameters and reduced bladder overactivity [2].
References:
[1]. Vandevoorde, S.,Lavand'homme, P.,Fowler, C.J., et al. Oleoylethylamide, an analgesic FAAH inhibitor which modulates endogenous anandamide, oleoylethanolamide, and 2-arachidonoylglycerol levels in the brain. 14th Annual Symposium on the Cannabinoids 15-15 (2004).
[2]. Gandaglia G, Strittmatter F, La Croce G, et al. The fatty acid amide hydrolase inhibitor oleoyl ethyl amide counteracts bladder overactivity in female rats. Neurourol Urodyn. 2014 Nov;33(8):1251-8.
Cas No. | 85075-82-7 | SDF | |
المرادفات | OEtA,N-Ethyloleamide | ||
Chemical Name | N-ethyl-9Z-octadecenamide | ||
Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)NCC | ||
Formula | C20H39NO | M.Wt | 309.5 |
الذوبان | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 3.231 mL | 16.1551 mL | 32.3102 mL |
5 mM | 0.6462 mL | 3.231 mL | 6.462 mL |
10 mM | 0.3231 mL | 1.6155 mL | 3.231 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5
(Based on Reviews and 19 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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