Tyk2-IN-8 |
| رقم الكتالوجGC37847 |
Tyk2-IN-8 (المركب 3) هو مثبط انتقائي Tyk-2 مع IC50 من 5.7 نانومتر لـ TYK2-JH2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2127109-84-4
Sample solution is provided at 25 µL, 10mM.
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Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1]. IC50: 17 nM (TYK2 JH1)[1]
Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].
[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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