PA 8 |
| رقم الكتالوجGC50538 |
PA 8 هو مضاد لمستقبلات PACAP من النوع الأول (PAC1) فعالة وانتقائية وفعالة عن طريق الفم.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 878437-15-1
Sample solution is provided at 25 µL, 10mM.
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PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.
Takasaki et al (2018) In silico screening identified novel small-molecule antagonists of PAC1 receptor. J.Pharmacol.Exp.Ther. 365 1 PMID:29363578
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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