L-778123 hydrochloride (L-778,123 hydrochloride) |
| رقم الكتالوجGC32759 |
هيدروكلوريد L-778123 (L-778،123 هيدروكلوريد) هو مثبط لـ FPTase و GGPTase-I مع IC50 من 2 نانومتر و 98 نانومتر في تحديد تثبيط الإنزيم.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 253863-00-2
Sample solution is provided at 25 µL, 10mM.
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L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1]
[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. [2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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