PAβN dihydrochloride (MC-207,110 dihydrochloride) |
رقم الكتالوجGC32063
One-Click Copy Product Info
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PA&beta ؛ N ثنائي هيدروكلوريد (MC-207.110 ثنائي هيدروكلوريد) (MC-207110 ثنائي هيدروكلوريد) هو مثبط لمضخة التدفق.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 100929-99-5
Sample solution is provided at 25 µL, 10mM.
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PAβN dihydrochloride (MC-207,110 dihydrochloride) is a peptide mimetic compound that is a broad-spectrum bacterial efflux pump inhibitor (EPI)[1]. PAβN dihydrochloride is the first inhibitor of the resistance nodule cell differentiation (RND) family of efflux pumps in Gram-negative bacteria[2]. PAβN dihydrochloride reduces the resistance of Pseudomonas aeruginosa to fluoroquinolones[3]. PAβN dihydrochloride can cause a 2- to 2048-fold decrease in the MIC of antimicrobial agents known to be substrates of the CmeABC pump in all Campylobacter strains[4]. PAβN dihydrochloride can be used to evaluate the efficacy of new EPI candidates[5].
In vitro, treatment of Salmonella typhimurium cells with PAβN dihydrochloride (32μM) inhibited efflux activity, increased the accumulation of ethidium (Et+) and tetraphenylphosphine (TPP+) in cells, and stimulated Et+ fluorescence[6].
References:
[1] Y Mahmood H, Jamshidi S, Mark Sutton J, et al. Current advances in developing inhibitors of bacterial multidrug efflux pumps[J]. Current medicinal chemistry, 2016, 23(10): 1062-1081.
[2] Compagne N, Vieira Da Cruz A, Müller R T, et al. Update on the discovery of efflux pump inhibitors against critical priority Gram-negative bacteria[J]. Antibiotics, 2023, 12(1): 180.
[3] Rahbar M, Hamidi-Farahani R, Asgari A, et al. Expression of RND efflux pumps mediated antibiotic resistance in Pseudomonas aeruginosa clinical strains[J]. Microbial Pathogenesis, 2021, 153: 104789.
[4] Martinez A, Lin J. Effect of an efflux pump inhibitor on the function of the multidrug efflux pump CmeABC and antimicrobial resistance in Campylobacter[J]. Foodbourne Pathogens & Disease, 2006, 3(4): 393-402.
[5] Blankson G A. Structure-activity studies on bacterial efflux inhibitors[M]. Rutgers The State University of New Jersey, School of Graduate Studies, 2016.
[6] Sakalauskaitė S, Mikalayeva V, Daugelavičius R. Ethidium binding to Salmonella enterica ser. Typhimurium Cells and Salmon sperm DNA[J]. Molecules, 2021, 26(11): 3386.
| Cas No. | 100929-99-5 | SDF | |
| Canonical SMILES | O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2.Cl.Cl | ||
| Formula | C25H32Cl2N6O2 | M.Wt | 519.47 |
| الذوبان | DMSO : ≥ 100 mg/mL (192.50 mM);Water : 4mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.925 mL | 9.6252 mL | 19.2504 mL |
| 5 mM | 385 μL | 1.925 mL | 3.8501 mL |
| 10 mM | 192.5 μL | 962.5 μL | 1.925 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)