Pegaptanib sodium (Synonyms: EYE001; NX1838) |
| رقم الكتالوجGC64346 |
Pegaptanib sodium هو عبارة عن أبتامير RNA موجه ضد عامل نمو بطانة الأوعية الدموية (VEGF) -165
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Cas No.: 222716-86-1
Sample solution is provided at 25 µL, 10mM.
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Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) [1].
Pegaptanib also inhibits VEGF165-mediated phosphorylation of VEGFR2 and phospholipase Cγ and inhibited VEGF165-induced calcium mobilization in human umbilical vein endothelial cells[1].
[1]. Eugene W M Ng, et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006 Feb;5(2):123-32.
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