PfDHODH-IN-2 |
| رقم الكتالوجGC61177 |
PfDHODH-IN-2 ، مشتق من ثنائي هيدروثيوفينون (مركب 11) ، هو مثبط قوي للهيدروجيناز المنجلي (PfDHODH) مع IC50 من 1.11 ميكرومتر
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Cas No.: 425629-94-3
Sample solution is provided at 25 µL, 10mM.
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PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].
Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality[1].PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 µM) over hDHODH (IC50>50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 µM, respectively in whole cell assays[1].
[1]. Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
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