PfDHODH-IN-2 |
| Catalog No.GC61177 |
PfDHODH-IN-2, un dérivé de la dihydrothiophénone (Composé 11), est un puissant inhibiteur de la dihydroorotate déshydrogénase de Plasmodium falciparum (PfDHODH) avec une CI50 de 1,11 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 425629-94-3
Sample solution is provided at 25 µL, 10mM.
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PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].
Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality[1].PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 µM) over hDHODH (IC50>50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 µM, respectively in whole cell assays[1].
[1]. Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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