WRG-28 |
رقم الكتالوجGC38206 |
WRG-28 هو مثبط خيفي DDR2 انتقائي يعمل خارج الخلية ، مع IC50 من 230 نانومتر
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Cas No.: 1913291-02-7
Sample solution is provided at 25 µL, 10mM.
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.
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