PLX7922 |
| رقم الكتالوجGC64828 |
يمكن ربط PLX7922 ، وهو مثبط RAF ، بـ BRAFV600Eيمنع PLX7922 pERK في خطوط خلايا BRAFV600E ، وينشط pERK في خطوط خلايا NRAS المتحولة
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Cas No.: 1638772-61-8
Sample solution is provided at 25 µL, 10mM.
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PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].
[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.
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