Pomalidomide 4’-PEG2-azide |
| رقم الكتالوجGC62131 |
Pomalidomide 4&rsquo ؛ -PEG2-azide عبارة عن اتحاد مركب E3 ligase ligand-linker مُصنَّع يشتمل على يجند cereblon القائم على Pomalidomide ورابط مستخدم في تقنية PROTAC.
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Cas No.: 2271036-45-2
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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