Prosaikogenin G |
| رقم الكتالوجGC61210 |
يُظهر Prosaikogenin G ، المعزول من جذور Buleurum bicaule Helm (Apiaceae) ، تأثيرات مثبطة كبيرة على تكاثر خلايا الفئران mesangial الناجم عن Ang II
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Cas No.: 99365-23-8
Sample solution is provided at 25 µL, 10mM.
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Prosaikogenin G, isolated from the roots of Buleurum bicaule Helm (Apiaceae), exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney[1]. Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract[2].
Prosaikogenin G (25, 50 μM) has protective action on the kidney for their down-regulated activity to the rat mesangial cell line (MC) proliferation induced by Ang II (1 μM), and does not exhibit injury to the normal MC[1].
[1]. Nan Xu, et al. A new saikogenin from the roots of Bupleurum bicaule. Chin J Nat Med. 2014 Apr;12(4):305-8. [2]. Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19.
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