الصفحة الرئيسية>>Signaling Pathways>> Neuroscience>> Pain Research>>Reduced Haloperidol

Reduced Haloperidol (Synonyms: Haloperidol Metabolite II)

رقم الكتالوجGC44810

Reduced haloperidol is an active metabolite of haloperidol.

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Reduced Haloperidol التركيب الكيميائي

Cas No.: 34104-67-1

الحجم السعر المخزون الكميّة
5mg
83٫00
متوفر
10mg
160٫00
متوفر
25mg
357٫00
متوفر
50mg
672٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

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