Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(68)
- DNA Methyltransferase(41)
- HDAC(230)
- Histone Acetyltransferases(90)
- Histone Demethylases(110)
- Histone Methyltransferase(258)
- HIF(118)
- JAK(169)
- MBT Domains
- PARP(147)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(80)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(269)
- MicroRNA(29)
- Protein Arginine Deiminase(15)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1791)
- GC78957(2S,3R,4S)-ASX-173CAS: 2748800-07-7Purity: >99.00%
(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.
- GC79003WCY-8-67 TFAPurity: >99.00%
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.
- GC79045LY3295668 erbumineCAS: 1919888-07-5Purity: >98%
LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a K i values for AurA and AurB of 0.8 nM and 1038 nM respectively.
- GC79046HDAC-IN-98CAS: 3124773-51-6Purity: >98.00%
HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC 50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively.
- GC79047HDAC6-IN-75CAS: 400078-78-6Purity: >99.50%
HDAC6-IN-75 is a selective HDAC6 inhibitor with an IC 50 of 0.17 nM against HDAC6.
- GC79048HDAC1/3-IN-1CAS: 244289-53-0Purity: >99.50%
HDAC1/3-IN-1 is a selective HDAC1/3 inhibitor, with IC 50 values of 256 nM and 340.3 nM against HDAC1 and HDAC3, respectively.
- GC79051HDAC6-IN-85CAS: 948837-73-8Purity: >97.50%
HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC 50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively.
- GC79055HDAC11-IN-4Purity: >95.00%
HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC 50 of 13.49 nM and a K i of 2.2 nM.
- GC79058PARP1/NAMPT-IN-1CAS: 3084810-86-3Purity: >98.00%
PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC 50 values of 1.2 nM and 6.7 nM, respectively.
- GC79059SAP15 acetatePurity: >98.00%
SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3.
- GC79061PARP1-IN-56CAS: 1574367-80-8Purity: >99.00%
PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC78957 | (2S,3R,4S)-ASX-173 | 2748800-07-7 | >99.00% | |
(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173. | ||||
| GC78958 | TMLB-C16 | 2923531-50-2 | >99.00% | |
TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM. | ||||
| GC78961 | GPS167 | 3034312-19-8 | >98% | |
GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4. | ||||
| GC78962 | MS1129 | - | >98% | |
MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. | ||||
| GC79003 | WCY-8-67 TFA | - | >99.00% | |
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM. | ||||
| GC79044 | ATC12 | 384860-40-6 | >98% | |
ATC12 is a Aurora-A kinase inhibitor. | ||||
| GC79045 | LY3295668 erbumine | 1919888-07-5 | >98% | |
LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a K i values for AurA and AurB of 0.8 nM and 1038 nM respectively. | ||||
| GC79046 | HDAC-IN-98 | 3124773-51-6 | >98.00% | |
HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC 50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively. | ||||
| GC79047 | HDAC6-IN-75 | 400078-78-6 | >99.50% | |
HDAC6-IN-75 is a selective HDAC6 inhibitor with an IC 50 of 0.17 nM against HDAC6. | ||||
| GC79048 | HDAC1/3-IN-1 | 244289-53-0 | >99.50% | |
HDAC1/3-IN-1 is a selective HDAC1/3 inhibitor, with IC 50 values of 256 nM and 340.3 nM against HDAC1 and HDAC3, respectively. | ||||
| GC79049 | CG-1521 | 674767-29-4 | >95.50% | |
CG-1521 is a histone deacetylase ( HDAC ) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation. | ||||
| GC79050 | OUL312 | - | >99.00% | |
OUL312 is a potent PARP10 inhibitor ( IC 50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 ( IC 50 = 1500 nM). | ||||
| GC79051 | HDAC6-IN-85 | 948837-73-8 | >97.50% | |
HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC 50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively. | ||||
| GC79052 | HDAC10-IN-3 formic | - | >97.00% | |
| GC79053 | G194-0712 | 1029737-28-7 | >99.50% | |
G194-0712 is a selective histone deacetylase 5 ( HDAC5 ) activator with an EC 50 of 7.96 μM and a K d of 2.53 μM. | ||||
| GC79054 | PTER-IN-1 | 3114432-21-9 | >98.00% | |
PTERi is a selective inhibitor of PTER with selectivity towards HDACs. | ||||
| GC79055 | HDAC11-IN-4 | - | >95.00% | |
HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC 50 of 13.49 nM and a K i of 2.2 nM. | ||||
| GC79056 | KMR-206 | 2992741-10-1 | >99.50% | |
KMR-206 is a PARP7 inhibitor with an IC 50 of 13.7 nM. | ||||
| GC79057 | BF-175 | 1333375-02-2 | >98% | |
BF-175 is a selective SIRT1 agonist. | ||||
| GC79058 | PARP1/NAMPT-IN-1 | 3084810-86-3 | >98.00% | |
PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC 50 values of 1.2 nM and 6.7 nM, respectively. | ||||
| GC79059 | SAP15 acetate | - | >98.00% | |
SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. | ||||
| GC79060 | A-620223 | 272769-49-0 | >96.00% | |
A-620223 is a PARP-1 inhibitor with a K i of 8 nM against PARP-1 and EC 50 of 3 nM in a whole cell assay. | ||||
| GC79061 | PARP1-IN-56 | 1574367-80-8 | >99.00% | |
PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor. | ||||
| GC79062 | PCIP-1 | - | >98.50% | |
PCIP-1 is a PARP2 inhibitor. | ||||