GLPBio

Chromatin/Epigenetics

Read More about this category
Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1791)

  • GC79063 structure
    GC79063TNKS-IN-1
    CAS: 59455-93-5
    Purity: >99.50%

    TNKS-IN-1 is a selective and potent tankyrase ( TNKS1 / TNKS2 ) inhibitor with IC 50 values of 7.9 nM and 8.7 nM.

  • GC79070 structure
    GC79070WWQ-03-012
    CAS: 3076807-15-0
    Purity: >98.00%

    WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM.

  • GC79072 structure
    GC79072MS6076
    Purity: >98%

    MS6076 is a mitochondrial protease ClpP agonist.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC79142 structure
    GC79142HA2 peptide
    CAS: 117138-19-9
    Purity: >98.00%

    HA2 peptide is a potent pH-responsive fusion peptide derived from hemagglutinin ( HA ), corresponding to the N-terminal fusion peptide domain consisting of 23 amino acid residues of HIV-1 gp41 envelope glycoprotein.

  • GC79143 structure
    GC79143BRD4-IN-12
    CAS: 3112325-99-9
    Purity: >98%

    BRD4-IN-12 is a potent and orally active BRD4 inhibitor with an IC 50 of 7.9 nM.

  • GC79144 structure
    GC79144MC3817 free base
    Purity: >98%

    MC3817 free base is a selective DNMT1 inhibitor.

  • GC79145 structure
    GC79145MC3817
    Purity: >99.50%

    MC3817 is a selective DNMT1 inhibitor.

  • GC79146 structure
    GC79146Ischemin
    CAS: 1357059-00-7
    Purity: >99.50%

    Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells.

  • GC79147 structure
    GC79147HLC40
    Purity: >99.50%

    HLC40 is a MLL1 histone methyltransferase inhibitor with an IC 50 of 0.82 μM by binding to WDR5.

  • GC79148 structure
    GC79148ZINC13000658
    CAS: 1324070-76-9
    Purity: >99.50%

    ZINC13000658 is a METTL inhibitor.

  • GC79149 structure
    GC79149WX2-43
    CAS: 723754-14-1
    Purity: >99.00%

    WX2-43 is a PRMT5-KLF4 inhibitor ( K d of 11.0 nM).

  • GC79150 structure
    GC79150NV914
    CAS: 2341941-41-9
    Purity: >98.50%

    NV914 is an inhibitor of FTSJ1 (tryptophan tRNA-specific 2'-O-methyltransferase) that inhibits the methyltransferase activity of FTSJ1, induces translational readthrough of premature termination codons, and enables genes carrying nonsense mutations to synthesize full-length proteins.

  • GC79151 structure
    GC79151DLG-41
    Purity: >98.00%

    DLG-41 is a GAS41 YEATS domain inhibitor ( IC 50 : 600 nM in AlphaLISA).

  • GC79152 structure
    GC79152cis-Revumenib
    Purity: >98.50%

    cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib.

  • GC79153 structure
    GC79153LS-170
    CAS: 3099617-79-2
    Purity: >99.50%

    LS-170 is a YEATS2 YEATS domain inhibitor with an IC 50 of 0.14 μM.

  • GC79154 structure
    GC79154BAY-7728
    CAS: 2767642-46-4
    Purity: >98.50%

    BAY-7728 is an orally active and selective dual inhibitor of KAT6A ( IC 50 : 45 nM)/ KAT6B ( IC 50 : 95 nM).

  • GC79155 structure
    GC79155Omvitrastat
    CAS: 3056105-63-3
    Purity: >99.50%

    Omvitrastat (OP-3136) is an orally active, highly selective inhibitor of KAT6A and KAT6B.

  • GC79156 structure
    GC79156SYY-B029-2
    CAS: 2379410-19-0
    Purity: >99.50%

    SYY-B029-2 is a potent histone acetyltransferase (HAT) inhibitor with an IC 50 of 1.4 nM.

  • GC79157 structure
    GC79157KDM4C-IN-2
    CAS: 23705-85-3
    Purity: >98.00%

    KDM4C-IN-2 is a histone lysine demethylase KDM4C ( JMJD2C ) inhibitor with an IC 50 of 147 μM and a K i of 51 μM.

  • GC79158 structure
    GC79158TNG917
    CAS: 2923223-81-6
    Purity: >98%

    TNG917 is a potent, selective EHMT1/2 inhibitor with oral activity.

  • GC79159 structure
    GC79159EZM8266
    CAS: 2140164-84-5
    Purity: >98.00%

    EZM8266 is an orally active and selective G9a ( EHMT2 ) histone methyltransferase inhibitor with a human EHMT2 IC 50 of 1 pM.

  • GC79160 structure
    GC79160TNG456
    CAS: 2962087-36-9
    Purity: >98%

    TNG456 is an orally active, CNS-penetrant, selective, MTA-cooperative PRMT5 inhibitor.

  • GC79161 structure
    GC79161MS2928
    Purity: >98%

    MS2928 is a selective SETD8 inhibitor with an IC 50 of 0.14 μM against SETD8 methyltransferase activity.