Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(68)
- DNA Methyltransferase(41)
- HDAC(230)
- Histone Acetyltransferases(90)
- Histone Demethylases(110)
- Histone Methyltransferase(258)
- HIF(118)
- JAK(169)
- MBT Domains
- PARP(147)
- Pim(32)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(80)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(269)
- MicroRNA(29)
- Protein Arginine Deiminase(15)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(14)
- METTL3(4)
- WDR5(3)
- TET Protein(2)
- HuR(1)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1791)
- GC79577PFKFB4-IN-1CAS: 2664831-55-2Purity: >99.50%
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.
- GC79669PHD-1-IN-4CAS: 2009343-19-3Purity: >99.50%
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .
- GC797782-PhenylcyclopropanamineCAS: 54-97-7Purity: >98.50%
2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1.
- GC79816CryptolepineCAS: 480-26-2Purity: >98%
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.
- GC79871CHNQD-00824CAS: 2222643-74-3Purity: >98%
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.
- GC80333Ac-QPKK(Ac)-AMC acetatePurity: >99.00%
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] .
- GC80334Rucaparib-d 3CAS: 2271225-13-7Purity: >98.00%
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib.
- GC80336(R)-JQ-1 carboxylic acidCAS: 202592-24-3Purity: >99.00%
(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid.
- GC80468Peficitinib-d 3Purity: >98%
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.
- GC80477Sodium butyrate-d 3CAS: 347840-05-5Purity: >99.50%
Sodium butyrate -d 3 (Butanoic acid-d 3 sodium) is the deuterium labeled Sodium butyrate.
- GC80857Enzomenib enantiomerPurity: >98.00%
Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib.
- GC80875PROTAC survivin degrader-1CAS: 3079079-69-6Purity: >98%
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.
- GC80877LD-110 triTFAPurity: >99.50%
LD-110 triTFA is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM).
- GC80889PROTAC HDAC4 Degrader-2CAS: 3035189-46-6Purity: >98%
PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC 50 of 0.15 μM against HDAC4 and a cellular IC 50 of 0.18 μM.
- GC80917LD-110 trihydrochloridePurity: >98.00%
LD-110 trihydrochloride is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79477 | KZ-02 | 1801756-14-8 | >98.00% | |
KZ-02 is an orally active dual MEK1 / Pim-1 kinase inhibitor, with an IC 50 of 1.07 nM against MEK1 and an IC 50 of 1.34 μM against Pim-1. | ||||
| GC79574 | mCPX | 1351572-56-9 | >98% | |
mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX). | ||||
| GC79577 | PFKFB4-IN-1 | 2664831-55-2 | >99.50% | |
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. | ||||
| GC79669 | PHD-1-IN-4 | 2009343-19-3 | >99.50% | |
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] . | ||||
| GC79670 | ZG-2686 | 1795110-22-3 | >98% | |
ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM. | ||||
| GC79671 | HIF-IN-2 | 1040535-05-4 | >95.00% | |
HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor. | ||||
| GC79778 | 2-Phenylcyclopropanamine | 54-97-7 | >98.50% | |
2-Phenylcyclopropanamine (Compound 3) is an irreversible inhibitor of MAO-A/B and LSD1. | ||||
| GC79816 | Cryptolepine | 480-26-2 | >98% | |
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. | ||||
| GC79871 | CHNQD-00824 | 2222643-74-3 | >98% | |
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect. | ||||
| GC80333 | Ac-QPKK(Ac)-AMC acetate | - | >99.00% | |
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] . | ||||
| GC80334 | Rucaparib-d 3 | 2271225-13-7 | >98.00% | |
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib. | ||||
| GC80335 | (S)-ML399 | 1560968-51-5 | >99.50% | |
(S)-ML399 (Compound 18S) is the enantiomer of ML399. | ||||
| GC80336 | (R)-JQ-1 carboxylic acid | 202592-24-3 | >99.00% | |
(R)-JQ-1 carboxylic acid, is an isomer of JQ-1 carboxylic acid. | ||||
| GC80468 | Peficitinib-d 3 | - | >98% | |
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib. | ||||
| GC80477 | Sodium butyrate-d 3 | 347840-05-5 | >99.50% | |
Sodium butyrate -d 3 (Butanoic acid-d 3 sodium) is the deuterium labeled Sodium butyrate. | ||||
| GC80483 | IOX2-NH2 | 931400-77-0 | >98.00% | |
IOX2 -NH2 (example 115) is a derivative of IOX2. | ||||
| GC80854 | (R)-BMS-986470 | - | >99.50% | |
(R)-BMS-986470 is the enantiomer of BMS-986470. | ||||
| GC80857 | Enzomenib enantiomer | - | >98.00% | |
Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib. | ||||
| GC80875 | PROTAC survivin degrader-1 | 3079079-69-6 | >98% | |
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC. | ||||
| GC80876 | G9D-4 TFA | - | >99.00% | |
G9D-4 TFA is a G9a PROTAC degrader. | ||||
| GC80877 | LD-110 triTFA | - | >99.50% | |
LD-110 triTFA is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM). | ||||
| GC80889 | PROTAC HDAC4 Degrader-2 | 3035189-46-6 | >98% | |
PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC 50 of 0.15 μM against HDAC4 and a cellular IC 50 of 0.18 μM. | ||||
| GC80916 | ZX079 | 3124583-65-6 | >98% | |
ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC 50 value of 0.035 nM and a CBP DC 50 value of < 0.02 nM. | ||||
| GC80917 | LD-110 trihydrochloride | - | >98.00% | |
LD-110 trihydrochloride is a highly efficient and effective LSD1 PROTAC degrader ( DC 50 = 0.44 μM). | ||||