GLPBio

Chromatin/Epigenetics

Read More about this category
Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1791)

  • GC80918 structure
    GC80918dCBP-30
    Purity: >98%

    dCBP-30 is an orally active, selective and dual-acting CBP/p300 PROTAC degrader with DC 50 values of 0.05 nM (CBP) and 0.04 nM (p300), respectively.

  • GC80919 structure
    GC80919AURKA-IN-4
    CAS: 89575-11-1
    Purity: >99.50%

    AURKA-IN-4 is a Capsaicin -derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A ( AURKA ) and PHB2.

  • GC80920 structure
    GC80920PROTAC PARP2 degrader-1
    CAS: 2925182-32-5
    Purity: >95.50%

    PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM.

  • GC80921 structure
    GC80921CCT400028
    Purity: >98.00%

    CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase.

  • GC80922 structure
    GC80922PROTAC HDAC6 degrader 7
    Purity: >98%

    PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 ( HDAC6 ) ( IC 50 = 118 nM).

  • GC80923 structure
    GC80923PROTAC HDAC degrader-2 TFA
    Purity: >96.50%

    PROTAC HDAC degrader-2 TFA is a selective class IIb dual histone deacetylase ( HDAC6 and HDAC10 ) PROTAC degrader, with DC 50 values of 13 nM and 29 nM against HDAC6 and HDAC10, respectively.

  • GC80924 structure
    GC80924iVeliparib-AP6
    CAS: 2472645-27-3
    Purity: >98%

    iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2.

  • GC80925 structure
    GC80925KAT2A/B ligand 1
    CAS: 2254066-18-5
    Purity: >99.00%

    KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand.

  • GC80926 structure
    GC80926BI-7273 acid
    CAS: 2097514-90-2
    Purity: >98.00%

    BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand.

  • GC80927 structure
    GC80927NSD2 ligand 2
    CAS: 3031353-62-2
    Purity: >98.50%

    NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2.

  • GC80928 structure
    GC80928NP1192
    CAS: 2966791-41-1
    Purity: >99.00%

    NP1192 is a potent, selective PROTAC NAT10 degrader.

  • GC80929 structure
    GC80929PLX-4104
    CAS: 2851986-77-9
    Purity: >98%

    PLX-4104 is an orally active BRD4 molecular glue degrader with a DC 50 of 2 nM.

  • GC80930 structure
    GC80930DNMT1 Degrader-1
    CAS: 2962943-72-0
    Purity: >99.00%

    DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC 50 of 202.87 nM and a Kd value of 122 nM.

  • GC80931 structure
    GC80931dHTC3
    Purity: >98%

    dHTC3 is a selective BRD4 molecular glue degrader.

  • GC80932 structure
    GC80932UNC10088
    Purity: >98%

    UNC10088 is a molecular glue targeting NSD2.

  • GC80933 structure
    GC80933AMX-883
    CAS: 3102636-19-8
    Purity: >98%

    AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia.

  • GC80934 structure
    GC80934PROTAC BRD4 Degrader-49
    CAS: 3115940-40-1
    Purity: >98%

    BRD4 degrader-8 is a BRD4 -targeting degrader.

  • GC80935 structure
    GC80935JQ1-JX5
    Purity: >98%

    JQ1-JX5 is a DCAF16-based BRD4 PROTAC degrader.

  • GC80936 structure
    GC80936PROTAC BLIMP-1 degrader-1
    Purity: >98.00%

    PROTAC BLIMP-1 degrader-1 is an orally active BLIMP-1 PROTAC degrader with an EC 50 of 13.1 nM.

  • GC80937 structure
    GC80937PROTAC KAT6 Degrader-1
    Purity: >98%

    PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader.

  • GC80938 structure
    GC80938DOT1L808
    Purity: >98.00%

    DOT1L808 is a potent and highly selective DOT1L PROTAC degrader with a DC 50 value of 5 nM.

  • GC80939 structure
    GC80939MS115 TFA
    CAS: 3109377-61-6
    Purity: >98.00%

    MS115 TFA is a selective PRMT5/MEP50 PROTAC degrader, with DC 50 values of 17.4 nM and 11.3 nM for PRMT5 and MEP50, respectively.

  • GC80946 structure
    GC80946PROTAC JAK1/2 degrader-1
    Purity: >99.00%

    PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.

  • GC80947 structure
    GC80947JAK1/2 ligand 1
    CAS: 1026028-96-5
    Purity: >99.50%

    JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.